Position Held:

• Feb 2020 - Present - Assistant Professor, Dept. of Immunology, Amala Cancer Research Centre, Thrissur, Kerala, India.
• Jan 2012- Feb 2020- Post-Doctoral Research Fellow, Cancer and Stem Cell Biology Program, DUKE- NUS Medical School, Singapore.
• Jan 2010 - Jan 2012 - Research Assistant, Dept. of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Research Interest:

• Metastasis,Cancer stem cell biology, Tumor immunology, Inflammation,RAS signalling, Post-translational lipid modifications, Cancer drug discovery.

Professional Memberships:

• Indian Association for Cancer Research (IACR) – lifemember
• American Association for Cancer Research (AACR)-Associate member
• European Association for cancer Research (EACR)

Publications:

• Chai, T.F.#, Manu, K.A.#(Equal First author), Casey, P.J. et al. Isoprenylcysteinecarboxylmethyltransferase is required for the impact of mutant KRAS on TAZ protein level and cancer cell self-renewal. Oncogene (2020). https://doi.org/10.1038/s41388-020-1364-7
• Manu KA, Cao PHA, Chai TF, Casey PJ, Wang M.p21cip1/waf1 Coordinate Autophagy, Proliferation and Apoptosis in Response to Metabolic Stress.Cancers (Basel). 2019 Aug 3;11(8). pii: E1112. doi: 10.3390/cancers11081112. (Review).
• Manu KA, Chai TF, Teh JT, Zhu WL, Casey PJ, Wang M. Inhibition of IsoprenylcysteineCarboxylmethyltransferase Induces Cell-Cycle Arrest and Apoptosis through p21 and p21-Regulated BNIP3 Induction in Pancreatic Cancer. Molecular Cancer Therapeutics . 2017 May;16(5):914-923. doi: 10.1158/1535-7163.MCT-16-0703. Epub 2017 Feb 6. PubMed PMID: 28167504.
• Shanmugam MK, Ahn KS, Lee JH, Kannaiyan R, Mustafa N, Manu KA, Siveen KS, Sethi G, Chng WJ, Kumar AP. Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma.Front Pharmacol. 2018 May 3;9:365. doi: 10.3389/fphar.2018.00365. eCollection 2018.
• Manu KA, Shanmugam MK, Ramachandran L, Li F, Siveen KS, Chinnathambi A, Zayed ME, Alharbi SA, Arfuso F, Kumar AP, Ahn KS, SethiG.Isorhamnetin augments the anti-tumor effect of capeciatbine through the negative regulation of NF-κBsignalling cascade in gastric cancer.Cancer Lett. 2015 Jul 10;363(1):28-36. doi: 10.1016/j.canlet.2015.03.033. Epub 2015 Mar 28 (Corrigendum Cancer Lett. 2018 Apr 28;420:259. doi: 10.1016/j.canlet.2018.01.003. Epub 2018 Jan 17.)
• Kanjoormana A. Manu, Muthu K. Shanmugam, Feng Li1, Luxi Chen, KodappullySivaramanSiveen, Kwang Seok Ahn, Alan Prem Kumar Gautam Sethi.. Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine